Europeanatolia Health Sciences Journal

Analysis Of Demographic, Clinicopathologic and Oncologic Outcomes of Patients with Operated Colorectal Signet Ring Cell Carcinoma

2025-09-25T01:06:46+03:00

Introduction: Colorectal signet ring cell carcinoma is a rarely encountered histopathological subtype of colorectal adenocarcinoma and displays unique clinicopathological and prognostic characteristics.

Objective: In order to extend the expected survival time and improve the quality of life, this study aimed to determine the factors affecting survival.

Method: This retrospective study was directed towards examining the clinicopathological features of colorectal signet ring cell carcinoma and to investigate prognostic factors affecting survival of the patients. Of 2622 patients having colorectal surgery in a state hospital between 1 January 2015 and 1 June 2025, 30 were found to have colorectal signet ring cell carcinoma and included in the study. Kaplan-Meier method was adopted to calculate the rates of cumulative events and Log-rank test was utilized for comparison of survival in terms of prognostic factors.

Results: Curative surgery created a significant difference in survival. In fact, the patients undergoing curative surgery had longer survival. However, female gender, T4 invasion depth, N2-N3 lymph node involvement, presence of metastasis and a stage 3C or higher stage of disease were found to be the factors of poor prognosis.

Conclusion: This study has a retrospective design. Therefore, randomized studies are needed to understand the biological behavior of signet ring cell adenocarcinoma and to determine prognostic factors that can affect survival.

Diagnostic Value Of Blood-Soluble Urokinase Plasminogen Activator Receptor Levels In Brucellosis

2025-10-30T11:22:19+03:00

Objective: Plasma suPAR levels indicate immune activation. This research aimed to determine whether there was a difference in serum suPAR levels between patients with brucellosis and the control group and to evaluate the diagnostic value of serum suPAR levels.

Methods: A total of 46 patients with brucellosis diagnosed clinically, serologically, and bacteriologically at our institution were included in the study: 21 acute, 15 subacute, and 10 chronic. Twenty-eight of the patients were male, and 18 were female. The control group included 35 healthy individuals (26 female and 9 male) with no prior history of brucellosis.

Results: Serum suPAR levels were significantly higher in the brucellosis group than in the control group. This difference was statistically significant (p <0.001). When CRP and suPAR levels were compared, suPAR levels were significantly higher in patients with CRP values above the threshold value. This difference was statistically significant (p = 0.04). When serum suPAR levels were compared in patients with acute, subacute, and chronic brucellosis, no statistically significant difference was found, unlike between the patient and control groups (p = 0.697). Pre-treatment SUPAR levels were higher in patients under treatment and in those who completed treatment, and the difference was statistically significant (p = 0.033).

Conclusion: This research demonstrated that suPAR levels can be a diagnostic marker for brucellosis, but these values cannot be used to distinguish between acute, subacute, and chronic forms of the disease. Studies with larger patient populations are necessary to confirm the biological significance of the results.

The Effect of Pre- And Post-Operative Prognostic Values on Patient Survival in Patients With Stomach Cancer

2025-11-21T18:07:22+03:00

Objective: Prognostic values in gastric cancer have been frequently investigated in the literature. While some studies have yielded similar results, others have been the subject of debate. In our study, we examined several preoperative and postoperative parameters to evaluate factors that may influence prognosis. This study retrospectively evaluated the prognostic factors and investigated their impact on postoperative patient survival.

Methods: This retrospective study examined the clinical records, pathological results, and operative reports of 180 patients who underwent elective surgery for gastric cancer at the General Surgery Clinic of Kocaeli University Faculty of Medicine Research and Practice Hospital between January 2017 and December 2020.

Results: The impact of different surgical procedures on patient survival: 61.2% of patients who underwent total gastrectomy, 68.4% who underwent subtotal gastrectomy, and 43.7% who underwent other surgical procedures survived. Among patients with Stage 0+1 disease, 83.8% survived, whereas this rate was lower in patients with other stages (p = 0.007). These results suggest that tumor metastasis plays an important role in treatment effectiveness and patient survival (p = 0.004). The presence of lymph node metastases significantly impacts cancer patients' survival (p = 0.004). The rate of metastases in dissected lymph nodes was also significant in multivariate analysis (p = 0.041).

Conclusion: In this study, when evaluated univariately, four values (stage, presence of lymph node metastasis, serosa invasion, and metastasis rate in the dissected lymph node) were predictive of prognosis, whereas, when analyzed multivariately, only one value (metastasis rate in the dissected lymph node) was significant.

Relationship Between Upper and Lower Extremity Functional Capacity and Clinical Parameters in Individuals With COPD

2025-12-05T15:54:10+03:00

Introduction: Chronic Obstructive Pulmonary Disease-(COPD) leads to loss of function in the muscles of the upper and lower extremities, thereby negatively affecting activities of daily living and quality of life. Therefore, it is important to determine the relationships among functional capacity–assessing tests themselves and with clinical parameters.

Aim: To examine the relationships between lower and upper extremity functional capacity measurements and clinical parameters according to disease severity, as well as their interrelationships, in individuals with COPD, thereby revealing the heterogeneous effects of COPD on muscle functions.

Methods: Seventy-one patients diagnosed with COPD according to the GOLD 2023 criteria were received in the evaluation. The demographic characteristics of the participants were recorded. Lower extremity functional capacity was assessed using the 6-Minute Walk Test-(6MWT), while upper extremity functional capacity was evaluated with the 6-Minute Pegboard and Ring Test-(6PBRT). Clinical parameters included CAT, dyspnea and fatigue severity, pulmonary function tests, handgrip, and peripheral muscle strength.

Results: The mean age was 65.4±9.3 years, and 42 (59.2%) of the patients were in GOLD Stage A. A moderate, positive correlation was found between 6MWT and 6PBRT (r=0.544; p<0.001). The results of 6MWT were positively associated with pulmonary function, handgrip strength, and peripheral muscle strength (p<0.05), and negatively associated with dyspnea (p<0.05). The 6MPRT was positively correlate only with handgrip strengths (p<0.05).

Conclusion: In COPD, lower and upper extremity functional capacities are interrelated in a complementary manner. Studies conducted with larger sample groups may clarify the clinical value of these tests, particularly in planning pulmonary rehabilitation.