Europeanatolia Health Sciences Journal

Trigger Factors and Effects of Alzheimer's Disease

Şükran Erdoğdu — Sat, 20 Apr 2024 00:00:00 +0300

Alzheimer's Disease is a neurodegenerative disorder characterised by symptoms such as cognitive decline, memory loss and decreased activities of daily living. Factors that play a role in the development of this disease include genetic, environmental and neurobiological factors. The importance of genetic factors has been associated with early onset of the disease and family history. Environmental factors include lifestyle factors such as toxic metals, pesticides, nutrition, exercise and sleep patterns. Neurobiological mechanisms include amyloid cascade hypothesis, hyperphosphorylation of tau proteins, oxidative stress and inflammation. Alzheimer's Disease is diagnosed through clinical assessments and cognitive testing, and treatment options focus on symptom relief. Future research should aim to deepen our understanding of the aetiology and pathogenesis of the disease and develop more effective treatment and prevention strategies. The complex nature of Alzheimer's Disease is determined by the interaction of genetic, environmental and neurobiological factors and understanding these factors plays an important role in the management of the disease.

Mini Review: Clicinal Strategies for Carbon monoxide Poisoning

Kemal Alp Nalcı, Umut Furkan Bayram — Sat, 20 Apr 2024 00:00:00 +0300

Carbon monoxide is a type of tasteless, colorless, odorless gas that occurs as a result of incomplete combustion of organic/inorganic hydrocarbons. He is defined as the "silent killer" based on these three physical characteristics. Poisoning is seen especially in winter months due to chimney systems used in rural areas (poisoning caused by suicide and exhaust may also be seen). In a study conducted in our country, it was shown that most of the exposure to carbon monoxide gas between 1993 and 2006 was caused by stoves and water heaters without any suicidal intent. It has been stated that the affinity of carbon monoxide to the tetramer receptor region in hemoglobin is approximately 200-250 times higher than that of the oxygen molecule, resulting in hypoxia and relative anemia. Additionally, by binding to cardiac myoglobin, it causes myocardial depression and hypotension. It plays a role in the activation of platelets, causing myeloperoxidase release, high oxidative stress, inflammation, and deterioration of cellular respiration by binding and inactivating reduced cytochrome a3. Intoxication resulting from these mechanisms must be treated as soon as possible. Otherwise, life-threatening situations may occur. The first symptoms of carbon monoxide intoxication are non-specific. Physical examination findings have a limited place in diagnosis. The relationship between disease history and carboxyhemoglobin is the most reliable diagnostic tool. There is no chemical or physiological antidote for poisoning. In first aid, advanced life support steps must be applied depending on whether the patient is conscious or unconscious. Hyperbaric oxygen therapy dramatically increases patient survival and is now recommended as the gold standard treatment by separating carbon monoxide bound to hemoglobin.

Use of Nanotechnology in Medical Biochemistry

Fatmanur Zeytindal — Sat, 20 Apr 2024 00:00:00 +0300

Dear Editor

Nanotechnology has an important place in the field of biochemistry/chemistry. The utilisation of nanotechnology in this field is of great importance. We would like to emphasise the importance and effects of nanotechnology in the field of chemistry and highlight the recent developments in this field.

Nanotechnology has become an important focus of interest in the field of chemistry in recent years. This technology enables the design and production of new materials by controlling matter at the atomic or molecular level. In particular, the unique physical, chemical and optical properties of nanomaterials lead to revolutionary applications in many fields.

Research shows that nanotechnology has great potential in various fields such as medicine, electronics, energy storage, environmental protection and materials science. For example, more effective and less invasive methods can be developed in cancer treatment with the use of nanoparticles. In addition, energy technologies such as solar cells and battery storage systems can be made more efficient thanks to nanotechnology (1-5).

In this context, the role and impact of nanotechnology in the field of chemistry should be understood more comprehensively. More research and co-operation is needed to fully exploit the potential of this technology and to translate it into industrial applications.

I would like to ask you to publish articles in the field of nanotechnology to bring this important topic to a wider audience and to encourage scientists to do more work in this field.

Best regards.