İnsülin Direnci Ve Diyabette Eser Element Ve Minerallerin Rolü
Araştırma Makalesi
DOI:
https://doi.org/10.5281/zenodo.8321078Anahtar Kelimeler:
İnsülin, Diyabet, Eser Elementler, MinerallerÖzet
Mineraller ve eser elementler insan vücudu için gerekli olan ancak yalnızca izlenebilir miktarlarda bulunan mikro besinlerdir. Bununla birlikte, iyi tanımlanmış biyokimyasal işlevler sergilerler. Bu mikro besinlerdeki eksiklikler yaygın insan sağlığı sorunlarıyla ilişkilidir. Bu makale, bu mineral ve eser element eksikliklerinden bazılarına ve bunların diyabet ve insülin direncindeki sonuçlarına odaklanmaktadır. Beslenmede selenyum, çinko, bakır, demir, krom ve iyot açısından yerel farklılıklar hem gelişmiş hem de gelişmekte olan ülkelerde ortaya çıkmaktadır.Bu genel eksiklikler ve birkaç vakada esansiyel eser elementlerin fazlalığı, glikoz homeostazisinde ve insülin direncinde dengesizliklere yol açabilir. Dünya çapında bir milyar veya daha fazla insanı etkileyen en kapsamlı sorunlar, aralarında iyot (I), selenyum (Se), çinko (Zn), kalsiyum (Ca), krom (Cr), kobalt (Co), demir (Fe), bor (B) ve magnezyumun (Mg) da bulunduğu bir dizi mineral ve eser elementin yetersiz tedarikiyle ilişkilidir. Bu makale; bazı insan popülasyonundaki diyabet ve insülin direnci üzerindeki mikro besin eksikliklerinin önemli sonuçlarını gösteren çeşitli randomize kontrollü çalışmaları, kohort ve vaka kontrollü çalışmaları ve gözlemsel-laboratuvar bazlı çalışmaları içermektedir.
Referanslar
Calabrese EJ, Canada AT, Sacco C. Trace Elements and Public Health. Annu. Rev., Public Health.1985;6:131–146.
Young VR. Trace element biology: The knowledge base and its application for the nutrition of individuals and populations. J. Nutr. 2003;133:1581S–1587S.
Nordberg M, Nordberg GF. Trace element research-historical and future aspects. J. Trace Elements Med. Boil. 2016;38:46–52.
Badran M, Morsy R, Soliman H,et al. Assessment of trace elements levels in patients with Type 2 diabetes using multivariate statistical analysis. J. Trace Elements Med. Boil. 2016;33:114–119.
Wolide AD, Zawdie B, Alemayehu T,et al. Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: A cross sectional study. BMC Endocr.Disord. 2017;17:64.
Sun W, Yang J, Wang W,et al. The beneficial e_ects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes.J. Trace Elements Med. Boil. 2018;46:117–127.
Kashiv Y, Austin JR, Lai B,et al. Imaging trace element distributions in single organelles and subcellular features. Sci. Rep. 2016;6:21437.
Derakhshanian H, Javanbakht M, Zarei M,et al. Vitamin D increases IGF-I and insülin levels in experimental diabetic rats. Growth Horm.IGF Res. 2017;36:57–59.
Sujatha P. Trace Elements in Diabetes Mellitus.J. Clin. Diagn. Res. 2013;7:1863–1865.
Zofkova I, Nemcikova P, Matucha P. Trace elements and bone health. Clin. Chem. Lab. Med. 2013;51:1–7.
Bakken NA, Hunt CD.Dietary Boron Decreases Peak Pancreatic In Situ Insulin Release in Chicks and Plasma Insulin Concentrations in Rats Regardless of Vitamin D or Magnesium Status.J. Nutr. 2003;133:3577–3583.
Caglar GS, Çakal GÖ, Yüce E,et al. Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes. J. Périnat. Med. 2012;40.
Coban FK, Ince S, Kucukkurt I,et al. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem. Toxicol. 2014;38:391–399.
Chen C, Jiang W, Zhong N,et al. Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome. Schizophr. Res. 2014;159:478–484.
Kanchana N, Saikumar P. Serum Calcium Levels In Type 2 Diabetes Mellitus. IOSR J. Dent. Med. Sci. 2014;13:1–3.
Kim MK, Kim G, Jang EH,et al. Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects: The Chungju Metabolic Disease Cohort study (CMC study). Atherosclerosis. 2010;212:674–681.
Sun G, Vasdev S, Martin G, et al. Altered Calcium Homeostasis Is Correlated With Abnormalities of Fasting Serum Glucose, Insulin Resistance, and -Cell Function in the Newfoundland Population. Diabetes. 2005;54:3336–3339.
Saker F, Ybarra J, Leahy P, et al. Glycemia-lowering e_ect of cobalt chloride in the diabetic rat: Role of decreased gluconeogenesis. Am. J. Physiol. Content. 1998;274:E984–E991.
Cao J, Vecoli C, NegliaD, et al. Cobalt-Protoporphyrin Improves Heart Function by Blunting Oxidative Stress and Restoring NO Synthase Equilibrium in an Animal Model of Experimental Diabetes. Front. Physiol. 2012;3.
Anjum A. Comparative study on calcium, magnesium and cobalt in diabetic and non diabetic patients (males) in Punjab, Pakistan. Afr. J. Biotechnol. 2012;11:7258–7262.
Flores CR, Puga MP, Wrobel K,et al. Trace elements status in diabetes mellitus type 2: Possible role of the interaction between molybdenum and copper in the progress of typical complications. Diabetes Res. Clin.Pract. 2011;91:333–341.
Mertz W, Schwarz K. Impaired intravenous glucose tolerance as an early sign of dietary necrotic liver degeneration. Arch. Biochem. Biophys. 1955;58:504–506.
Anderson RA, Polansky MM, Bryden NA,et al. Chromium supplementation of human subjects: E_ects on glucose, insulin, and lipid variables. Metabolism. 1983;32:894–899.
Cheng Y, Ma W, Li X, et al. Polyamines stimulate hyphal branching and infection in the early stage of Glomusetunicatum colonization. World J. Microbiol.Biotechnol. 2011;28: 1615–1621.
Anderson RA. Nutritional factors influencing the glucose/insulin system: Chromium. J. Am. Coll. Nutr. 1997;16:404–410.
Sun Z, Wang X, Chen J, et al. Ejects of iodine excess on islet beta cells(beta-TC-6) function and the mechanism. J. Hyg. Res. 2017;46:610–614.
Al-Attas OS, Al-Daghri N, Alkharfy KM,et al. Urinary Iodine is Associated with Insulin Resistance in Subjects with Diabetes Mellitus Type 2. Exp. Clin. Endocrinol. Diabetes. 2012;120:618–622.
Gierach M, Gierach J, Junik R. Insulinooporno´s´c a chorobytarczycy. Endokrynol.Polska. 2014;65:70–76.
Fernandez-Real JM,López-Bermejo A, Ricart-Engel W, Cross-talk between iron metabolism and diabetes.Diabetes. 2002;51:2348–2354.
Thomas M, MacIsaac RJ, Tsalamandris C, et al. Elevated iron indices in patients with diabetes. Diabet. Med. 2004;21:798–802.
Jiang R, Manson JE, Meigs JB,et al. Body Iron Stores in Relation to Risk of Type 2 Diabetes in Apparently Healthy Women. JAMA. 2004;291:711–717.
İndir
Yayınlanmış
Nasıl Atıf Yapılır
Sayı
Bölüm
Lisans
Telif Hakkı (c) 2023 Europeanatolia Health Sciences Journal
Bu çalışma Creative Commons Attribution 4.0 International License ile lisanslanmıştır.
